Popular on Rezul
- No Limits Method Revolutionizes Neurodivergent Education Through Embodied Cognition - 107
- Corner Property Management Welcomes Seneca Reserve HOA! - 104
- Kaplan Morrell Applauds Passage of Landmark Workers' Compensation Reform in Colorado
- First AI Marketing Platform Built Specifically for Small Businesses Launches Public Beta
- TEDxInglewood Returns to The Miracle Theater on August 9, 2025 — Celebrating Bold Ideas and Community Energy
- Rediscovered Christopher Lee Recording 'Elenore' Re-Released to Mark 10th Anniversary of His Passing
- Conexwest Expands Single-Phase Cold Storage Lineup: Versatile Solutions for Diverse Temperature Needs
- Manhattan Boutique Real Estate Collaborates with InterContinental Hotels NYC in a Branding Partners Personalized Approach
- Honoring Black History, Culture, and Community in Fall River
- Token-Operated Sake Service Opens at Tobu Nikko Station
Similar on Rezul
- New Podcast "Spreading the Good BUZZ" Hosted by Josh and Heidi Case Launches July 7th with Explosive Global Reach and a Mission to Transform Lives
- Digital Watchdog Launches New myDW Cloud Services
- Stan Fitzgerald Appointed Acting Press Secretary for Veterans for America First VFAF Georgia State Chapter
- AI Innovation Dual-Strategy Business Model Focused on Real Estate Development for Strategic Expansion: OFA Group, (N A S D A Q: OFAL)
- Eolian Signs New Information Exchange Agreement with the U.S. Department of Defense for Technology Innovation
- Top Dentist Concord CA, Smile Makers Dental Care, Celebrates 500 5-Star Reviews
- Valley Sleep Therapy Expands to Prescott with New Location at Crossings Road
- $17.4 Million Total Revenue for First Half of 2025 (up 31.8% YOY) for Global Wet Trades Services Provider with High Value Bitcoin Investments
- Inked & Maxim Model Teisha Mechetti Turns Heads—And Builds Community Impact
- Plan to Launch Silo Technologies' Cybersecurity Pilot Program for Ultimate Nationwide Deployment via Exclusive Partnership: Stock Symbol: BULT
Long-term results with the Tat vaccine point to a new approach for a functional cure of HIV
Rezul News/10408921
ROME, Italy - Feb. 16, 2019 - Rezul -- A new study announced by Istituto Superiore di Sanità (ISS, Rome, Italy) and published in "Frontiers in Immunology, February 13, 2019" suggests new avenues toward cure of HIV: the administration of the recombinant HIV-1 Tat protein (rTAT) to people living with HIV on antiretroviral therapy drastically reduced the "latent virus reservoir", which is invulnerable to HIV drugs. The rTAT has been developed at the National HIV/AIDS Research Center of the Istituto Superiore di Sanità (Rome, Italy), under the leadership of its Director, Dr Barbara Ensoli.
The results announced by ISS open new perspectives for a "functional" cure of HIV, i.e. the ability to control the virus during the suspension of antiretroviral drugs; a functional cure would ease the long-term clinical management of people with HIV by reducing the cumulative toxicity of antiretroviral drugs while improving adherence to therapy and quality of life that are crucial especially for children and adolescents.
Almost 40 years from the discovery of the virus, HIV/AIDS remains a global emergency, particularly for the poorest and most vulnerable populations in the world: women and children, homosexuals, bisexuals and transgenders (LGBT), sex workers, migrants, and users of injectable drugs. To date, almost 40 million people in the world live with HIV infection, half of them without any treatment, and international agencies are calling for a renewed effort, more investments and innovative strategies to find a cure for HIV and eradicate the virus.
More on Rezul News
Strict adherence to lifelong therapy is required to control HIV, in fact the virus hides in the "virus reservoir" as silent viral DNA invisible to the immune system and to antiretroviral therapy (ART), but it reactivates once therapy is interrupted. In the new study entitled "Continued decay of HIV proviral DNA upon vaccination with HIV-1 Tat of subjects on long-term ART: an 8-year follow-up study", published in the open access journal "Frontiers in Immunology", February 13, the authors present data of the long-term clinical monitoring of 92 volunteers who completed the previous phase II clinical trial in Italy (ISS T-002 ClinicalTrials.gov NCT00751595) and enrolled in the extended follow-up (ISS T-002 EF-UP, ClinicalTrials.gov NCT02118168). The 8-year study was conducted in 8 clinical sites in Italy: San Raffaele Hospital in Milan, L. Sacco Hospital of the University of Milan, San Gerardo Hospital in Monza, University Hospital of Ferrara, Policlinic Hospital of the University of Modena, Santa Maria Annunziata Hospital in Florence, San Gallicano Dermatological Institute in Rome, and the Policlinic Hospital in Bari. The results suggest new avenues towards a "functional cure" and, in perspective, the eradication of HIV.
The study shows that the volunteers treated with rTAT after being on ART for an average of 6 years, experienced, during the following 8 years, a continued decrease of viral DNA in blood, which occurred at an average speed 4-7 times greater than that observed in similar studies in patients treated with ART alone. Furthermore, in the vaccinated volunteers the reduction of the virus reservoir was associated with an increase in CD4+ T-cell number and CD4+/CD8+ T-cell ratio. A very small reservoir of latent virus (as evidenced by the low levels of proviral DNA in blood), and a good recovery of the immune system (as indicated by a high ratio of CD4+/CD8+ T lymphocytes) are found also in rare patients called "post-treatment controllers", who can control the reactivation of HIV after discontinuing therapy.
More on Rezul News
It is therefore conceivable that vaccination with Tat may confer to patients the ability to become post-treatment controllers, i.e. to control the virus without taking medications for periods of time the duration of which will be evaluated with specific clinical studies. Therefore, the results of the study lead to programmed and controlled therapy interruptions in volunteers treated with ART and rTAT that are currently being planned in order to verify this hypothesis.
The economic impact of a HIV cure is expected to be substantial. HIV is taking vast resources from the fight against poverty and inequality in the world: $ 563 billion between 2000 and 2015, a taxpayer contribution of $ 100 dollars in developing countries and $ 5,000 in Europe and North America ($ 330/$ year); and a net loss of national wealth (GDP) in African countries of between - $ 30 - $ 150 billion a year ($450 billion -4.5 trillion in 15 years), huge figures that impose urgent and innovative therapeutic solutions for HIV/AIDS.
For more information visit http://www.vaxxit.com
The results announced by ISS open new perspectives for a "functional" cure of HIV, i.e. the ability to control the virus during the suspension of antiretroviral drugs; a functional cure would ease the long-term clinical management of people with HIV by reducing the cumulative toxicity of antiretroviral drugs while improving adherence to therapy and quality of life that are crucial especially for children and adolescents.
Almost 40 years from the discovery of the virus, HIV/AIDS remains a global emergency, particularly for the poorest and most vulnerable populations in the world: women and children, homosexuals, bisexuals and transgenders (LGBT), sex workers, migrants, and users of injectable drugs. To date, almost 40 million people in the world live with HIV infection, half of them without any treatment, and international agencies are calling for a renewed effort, more investments and innovative strategies to find a cure for HIV and eradicate the virus.
More on Rezul News
- Drone Light Shows Emerge as the New Standard in Live Event Entertainment
- Lore Link is Here to Help Organize Your Game
- Chappaqua's Annual Townwide Summer Sale – Unbeatable Savings at Your Favorite Local Boutiques!
- Skyline Partners with ZenSpace to Offer Private Meeting Pods for Trade Show Exhibitors
- Garden City Realty recognizes top REALTOR®s of the Month and Quarter
Strict adherence to lifelong therapy is required to control HIV, in fact the virus hides in the "virus reservoir" as silent viral DNA invisible to the immune system and to antiretroviral therapy (ART), but it reactivates once therapy is interrupted. In the new study entitled "Continued decay of HIV proviral DNA upon vaccination with HIV-1 Tat of subjects on long-term ART: an 8-year follow-up study", published in the open access journal "Frontiers in Immunology", February 13, the authors present data of the long-term clinical monitoring of 92 volunteers who completed the previous phase II clinical trial in Italy (ISS T-002 ClinicalTrials.gov NCT00751595) and enrolled in the extended follow-up (ISS T-002 EF-UP, ClinicalTrials.gov NCT02118168). The 8-year study was conducted in 8 clinical sites in Italy: San Raffaele Hospital in Milan, L. Sacco Hospital of the University of Milan, San Gerardo Hospital in Monza, University Hospital of Ferrara, Policlinic Hospital of the University of Modena, Santa Maria Annunziata Hospital in Florence, San Gallicano Dermatological Institute in Rome, and the Policlinic Hospital in Bari. The results suggest new avenues towards a "functional cure" and, in perspective, the eradication of HIV.
The study shows that the volunteers treated with rTAT after being on ART for an average of 6 years, experienced, during the following 8 years, a continued decrease of viral DNA in blood, which occurred at an average speed 4-7 times greater than that observed in similar studies in patients treated with ART alone. Furthermore, in the vaccinated volunteers the reduction of the virus reservoir was associated with an increase in CD4+ T-cell number and CD4+/CD8+ T-cell ratio. A very small reservoir of latent virus (as evidenced by the low levels of proviral DNA in blood), and a good recovery of the immune system (as indicated by a high ratio of CD4+/CD8+ T lymphocytes) are found also in rare patients called "post-treatment controllers", who can control the reactivation of HIV after discontinuing therapy.
More on Rezul News
- Maui Investment Property Realtor Shares the Wonders of Stargazing on Maui!
- Houston Office Market Report | Q2 2025
- Yes, Islamorada is The Fishing Capital of The World, Here's Why!
- Corner Property Management Selected as New Management Company for Orange COA
- AI Innovation Dual-Strategy Business Model Focused on Real Estate Development for Strategic Expansion: OFA Group, (N A S D A Q: OFAL)
It is therefore conceivable that vaccination with Tat may confer to patients the ability to become post-treatment controllers, i.e. to control the virus without taking medications for periods of time the duration of which will be evaluated with specific clinical studies. Therefore, the results of the study lead to programmed and controlled therapy interruptions in volunteers treated with ART and rTAT that are currently being planned in order to verify this hypothesis.
The economic impact of a HIV cure is expected to be substantial. HIV is taking vast resources from the fight against poverty and inequality in the world: $ 563 billion between 2000 and 2015, a taxpayer contribution of $ 100 dollars in developing countries and $ 5,000 in Europe and North America ($ 330/$ year); and a net loss of national wealth (GDP) in African countries of between - $ 30 - $ 150 billion a year ($450 billion -4.5 trillion in 15 years), huge figures that impose urgent and innovative therapeutic solutions for HIV/AIDS.
For more information visit http://www.vaxxit.com
Source: Vaxxit
Filed Under: Investment
0 Comments
Latest on Rezul News
- $17.4 Million Total Revenue for First Half of 2025 (up 31.8% YOY) for Global Wet Trades Services Provider with High Value Bitcoin Investments
- $12.8 Million Net Revenue for 2024 for Cloud-Based Crowdsourcing Recruitment and SaaS-Enabled HR Solutions Provider: Baiya International Group Inc
- Salazar Heating, Cooling & Plumbing Launches Water Conservation Initiative to Help Santa Fe Homeowners Cut Water Waste
- Hire Virtue Announces Executive Sponsorship Opportunity for Houston Hiring Blitz & Job Fair on August 6, 2025
- Inked & Maxim Model Teisha Mechetti Turns Heads—And Builds Community Impact
- Winners Development Corporation Pioneers Skyscraper In South Dallas
- Plan to Launch Silo Technologies' Cybersecurity Pilot Program for Ultimate Nationwide Deployment via Exclusive Partnership: Stock Symbol: BULT
- Robert Michael & Co. Real Estate Team Celebrates Industry Recognition and Showcases Premier Central Florida Listings
- Extreme Exterior Cleaning of Seaside Florida Home Separates Pros from Amateurs
- AI-Based Neurotoxin Countermeasure Initiative Launched to Address Emerging National Security Needs: Renovaro, Inc. (N A S D A Q: RENB)
- The Naturist World Just Shifted — NaturismRE Ignites a Global Resurgence
- San Antonio Board of REALTORS® Among First to Use Passkey Login with Solid Earth's SSO Dashboard
- CGI+ Sells Multifamily Development Site in Los Angeles' South Bay to JPI for $40 Million
- $796,000 in Q2 Revenue Marks Highest Earnings to Date on 3 Trailing Quarters of Profitability in Multi-Billion Homebuilding Sector: Stock Symbol: IVDN
- Cybersecurity is THE Hot Market Sector; Revenues, Earnings & Profit matter; Only 33 Million Shares + a Huge Short Position Equal an Undervalued Stock
- Despite Global Calls for a Ban, US Child Psychiatry Pushes Electroshock for Kids
- Franco Polished Plaster Celebrates 35 Years of Bringing Walls to Life in the UK
- Spartan & Guardians Partner with Guitar Legend Buckethead to Support Global Child Rescue Efforts
- Preliminary.online Introduces Short-Term Job-Readiness Courses with Employer-Verified Certifications
- Psychologist-Turned-Hermeticist Releases Modern Guide to the Seven Hermetic Principles